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Gaikwad, S. B.
- Ursodeoxycholic Acid as a Biliary Agent Used in the Treatment of Liver Disease: An Overview
Authors
1 P. Wadhwani College of Pharmacy, Yavatmal - 445001, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 6 (2010), Pagination: 355-362Abstract
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholeresis.Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as an adjunct to medical therapy has been well established. Newer indications include its use in the management of chronic hepatitis, cirrhosis, post liver transplant rejection, graft versus-host disease and acute viral hepatitis, where it not only relieves symptoms of holestasis but also arrests ongoing hepatocyte necrosis.
Keywords
Biliary Cirrhosis, Primary Sclerosing Cholangitis, Ursodeoxycholic Acid.References
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- Atibala: An Overview
Authors
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 3, No 2 (2011), Pagination: 29-37Abstract
Abutilon indicum is known as 'Atibala' in Sanskrit. Literally, 'Ati' means very and 'Bala' means powerful, referring to the properties of this plant as very powerful . A. indicum is a hairy herb or under shrub distributed throughout the tropica . In traditional systems of medicine, various plant parts such as ischolar_mains, leaves, flowers, bark, seeds, an d stems have been used as antioxidant, demulcent, laxative, diuretic, analgesic, anti - inflammatory, and antiulcer. The present review is therefore an effort to give the detailed survey of literature on its pharamcognosy, phytochemistry as well as tradition al and pharmacological uses.Keywords
Abutilon indicum, Atibala, Indian Mallow, Pharamcognosy, Phyto - Chemistry , Pharmacology.- Pellets as Controlled Release Drug Delivery System: A Review
Authors
1 Department of Pharmaceutics, P. Wadhwani College of Pharmacy, Yavatmal (Maharashtra) 445001, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 179-183Abstract
In the recent years, considerable attention has been focused in the development of controlled release drug delivery system. The pellets have since long been used as an important formulation tool. Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small , free flowing , spherical or semispherical units referred to as pellets. Pellets range in size typically, between 500- 1500 μm. When pellet containing the active ingredient are administered in vivo in the form of suspension capsule or disintegrating tablets, they offer significant therapeutic advantage over single unit dosage forms. An ideal controlled drug delivery system is the one which delivers the drug at a predetermined rate, locally, or systemically, for a specified period of time. Controlled release pellet formulation can be formulated by many techniques such as extrusion/spheronization, powder layering, solution/suspension layering etc.
Various applications of pellets in controlled drug delivery system formulation, recent developments, polymer and excipients used for formulation of controlled release drug delivery system are discussed in this review.